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SM ISO690:2012 CAZAC, Victor, GROPPA, Liliana, RUSSU, Eugen, ROTARU, Larisa, CHIŞLARI, Lia. Relații între profilul clinic, metabolismul osos și riscul de fracturi de fragilitate în perioada postmenopauzală. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 196. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Background. Menopause is associated with metabolic changes, including changes in bone and mineral metabolism with possible development of osteoporosis. In the development of postmenopausal osteoporosis, multiple factors have been involved, such as age, asthenic constitution, low activity and vitamin D level. Objective of the study. To determine relationships between the clinical profile, bone metabolism and fragility fracture risk in postmenopausal women. Material and Methods. 74 postmenopausal, treatment-naïve women were evaluated clinically, with assessment of body mass index (BMI), adiposity index, bone metabolism markers, bone mineral profile (DXA). Fragility fracture risk was estimated (calibrated FRAX model for Moldova). Pearson correlation coefficients were calculated between clinical parameters, bone metabolism and mineral markers, as well as fracture risk. Results. Adiposity index revealed a negative correlation with major fragility fracture risk (r=0,579, p=0,000) as well as hip fracture risk (r=-0,556, p=0,000), whereas BMI yielded non-significant results. Age of menarche or menopause, number of births and pregnancies, β-CTX, serum osteocalcin, and serum vitamin D did not reveal significant relationships. Serum parathormone (PTH) values correlated inversely with major fracture risk. (r=-0,465, p=0,003), serum calcium was associated with increased major fracture risk (r=-0,426, p=0,006) as well as femoral hip fracture risk (r=0,330, p=0,037), while serum phosphate levels was associated with increase major fracture risk (r=0,610, p=0,000). Conclusion. Unlike BMI, adiposity index, together with serum calcium and phosphate have proven to be associated with a higher fragility fracture risk. Serum PTH values was associated with a reduced fracture risk, possibly due to the osteoanabolic effect of pulsatile PTH secretion. |
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Cuvinte-cheie adiposity index biomarker fractures, index adipozitate, biomarker, fracturi |
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