Background: The outcomes of NSTEMI patients are known to be worse than those of STEMI patients and depend on guideline-directed management. The higher the rate of adherence to guideline recommendations the better the prognosis and outcomes of usually high-risk NSTEMI patients. The best efforts should be made to rapidly and correctly diagnose and manage this condition in order to achieve the best results. Material and methods: An observational retrospective study was conducted in 3 PCI centers in Chisinau, Moldova, that included all patients hospitalized with NSTEMI through 2019. Another observational prospective study was conducted in the same 3 PCI centers with the consecutive inclusion of all NSTEMI patients in 2020-2021 and established follow-up dates. Results: Extensive preliminary data from both studies based on 215 patients is presented and compared to that of the FAST-MI registry in France, as an example of care in a developed country. Conclusions: Preliminary data has contoured a picture of NSTEMI patients management in Chisinau and has already detected major drawbacks to be corrected. The follow-up data will provide more insights on patient outcomes and correlations between management, short-term and long-term outcomes, whereas different biomarkers will be tested for diagnostic and prognostic values. Similar studies are needed in regional hospitals in order to assess the situation in these areas and search for improvement solutions.