<?xml version='1.0' encoding='utf-8'?>
<resource xmlns:xsi='http://www.w3.org/2001/XMLSchema-instance' xmlns='http://datacite.org/schema/kernel-3' xsi:schemaLocation='http://datacite.org/schema/kernel-3 http://schema.datacite.org/meta/kernel-3/metadata.xsd'>
<creators>
<creator>
<creatorName>Sofian, I.</creatorName>
<affiliation>Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu“, Moldova, Republica</affiliation>
</creator>
</creators>
<titles>
<title xml:lang='en'>Evaluation of combined pharmaceutical medicines used in hypopotassemia</title>
</titles>
<publisher>Instrumentul Bibliometric National</publisher>
<publicationYear>2018</publicationYear>
<relatedIdentifier relatedIdentifierType='ISBN' relationType='IsPartOf'></relatedIdentifier>
<subjects>
<subject>propolis</subject>
<subject>suppositories</subject>
<subject>extract</subject>
</subjects>
<dates>
<date dateType='Issued'>2018</date>
</dates>
<resourceType resourceTypeGeneral='Text'>Conference Paper</resourceType>
<descriptions>
<description xml:lang='en' descriptionType='Abstract'><p>Introduction. Propolis is known as one of natural products with multiple therapeutic effects, such as: antimicrobial, antibiotic, anti-inflammatory, analgesic, antioxidant, antifungal and anti-tumor. This apiculture product has a very complex composition, consisting of the following groups of active principles: phenols, flavonoids, amino acids, volatile oils, steroids, minerals, etc. The development of pharmaceutical forms with propolis extract is a very actual problem.&nbsp; Aim of the study. Technology development and standardization of suppositories with soft propolis extract.&nbsp; Materials and methods. Analysis of State Nomenclature of drugs of the Republic of Moldova. Use of hand rolling and molding methods and different excipients to prepare suppositories with propolis extract.&nbsp; Results. The analysis of State Nomenclature of drugs of the Republic of Moldova denotes a very low content of preparations with soft extract of propolis. Most of the suppositories have anti-inflammatory action (25%); followed by analgesic-antipyretic (15%); immunomodulators (14%), etc. &nbsp; Suppositories with soft propolis extract were formulated in the compounding department of Vasile Procopisin Pharmaceutical University Center. The excipients used were cocoa butter, PEG 4000:400 (9:1) and PEG 4000:1500:400 (6:3:1). The performed quality tests on appearance, melting rate, dissolution rate and uniformity of mass met the quality standards required by European Pharmacopoeia.&nbsp; Conclusions. The technology of preparation of suppositories with soft propolis extract by two methods, using different excipients was elaborated and quality assessment was performed. The results of the research will allow the introduction of suppositories with soft propolis extract in assortment of Vasile Procopisin Pharmaceutical University Center as elaborations.&nbsp;</p></description>
</descriptions>
<formats>
<format>application/pdf</format>
</formats>
</resource>