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SM ISO690:2012 CUROCICHIN, Ghenadie. Consecinţele metabolice ale rezistenţei la insulină şi riscul cardiovascular. In: Curierul Medical, 2008, nr. 5(305), pp. 68-72. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 5(305) / 2008 / ISSN 1875-0666 | ||||||
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Pag. 68-72 | ||||||
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The purpose of this study was to evaluate publications about possible pathogenetic pathways of high cardiovascular risk realization it is conferred by the metabolic syndrome. Accessible publications from PubMed and OVID databases were retrieved with a 17 year in-depth search limit. The search strategy used the following keywords: insulin resistance, hyperinsulinemia, metabolic syndrome, type 2 diabetes mellitus, cardiovascular risk, lipid metabolism, endothelial dysfunction, chronic inflammation, fibrinolysis”, arterial hypertension, and atherosclerosis. 103 publications with free full-text access were obtained and analyzed. We found that insulin resistance causes a wide spectrum of pathologic phenomena which facilitate the emergence and progression of cardiovascular disease. Increased risk of cardiovascular disease and type 2 diabetes mellitus linked to insulin resistance is mediated by disorders of lipid metabolism, endothelial dysfunction, chronic inflammation, deregulation of the fibrinolytic system, and arterial hypertension. Early detection of patients with insulin resistance and/or obvious metabolic syndrome, and timely preventive measures could considerably contribute to the reduction in the morbidity and mortality of cardiovascular disease and diabetes type 2. |
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Cuvinte-cheie insulin resistance, hyperinsulinemia, metabolic syndrome, сахарный диабет, метаболический синдром |
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