Introduction. Diabetic nephropathy is one of the most common causes of end-stage chronic kidney disease. Hyperglycemia and insulin resistance may lead to dyslipidemia. Dyslipidemia is one of the risk factors for the development of diabetic nephropathy. Aim of the study. To determine possible correlations between indicators of lipid profile parameters and violation renal function in patients with diabetic nephropathy. Material and methods. The study was performed on 67 patients who received medical treatment and care at the Chernivtsi Regional Clinical Hospital for a 3-month period. Women - 39 (58.21%) and men -28 (41.79%), mean age 62.8 ± 9.3 (40-65) years with diabetes duration of 10 - 15 years. The study groups included 36 patients with diabetic nephropathy III stage (group 1) and 31 patients with diabetic nephropathy IV stage (2 group). The control group were 17 healthy individuals. The levels of total cholesterol, triglycerides, high-density lipoproteins cholesterol, low-density lipoproteins cholesterol was determined in all subjects. Results. The levels of total cholesterol, triglycerides and low-density lipoproteins cholesterol were significantly higher in the case of patients with diabetic nephropathy compared with results of healthy individuals (p <0.05). The most significant imbalance of indicators of lipid metabolism was found in patients who had diabetic nephropathy IV stage (p <0.05). Conclusions. The level of lipid imbalance was most pronounced in patients with diabetic nephropathy IV stage. Diabetic dyslipidemia correlates with the progression of diabetic nephropathy. Correlation is moderate. To prevent deterioration of renal function is necessary timely diagnosis and the appointment of adequate treatment.