Introduction. Rheumatoid arthritis (RA) is a pathology that leads to functional impairment with functional deficits, affects the patient's normal activity and reduces its productivity. From an economic and social point of view, it has a negative impact on both his family and society, greatly reducing the quality of life of the patient. According to the WHO data, RA prevalence in the general population is 0.6 1.3% and annual incidence 0.02%. RA is an inflammatory, au toimmune disease of unknown etiology, which has a chronic and progressive evolution, affects the joints by symmetrical erosive arthritis and can be associated with extraarticular and systemic manifestations. Aim of the study. To study the affection of the nervous system in patients with RA, to improve their quality of life. We have proposed to find effective ways to prevent infirmity through RA. Materials and methods. We studied files of 50 patients who were suffering from RA and analyzed the results. Also, we studied specialized information and international publications with impact on the study. Of the 50 patients, 24 had oversegmental vegetative dysfunction with astenovegetative syndrome, 10 patients had paraesthesias, 4 patients had both. Of the 13 patients who had visceral RA, 10 of them had nerve damage. Results. have shown that the duration of the RA disease and the nervous disorder are not correlated. Patients with RA history less than 5 years are more likely to develop nerve complications. 10% of the RA patients had illness for less than 5 years, but they had already nerve damage, while 100% of patients without nervous disorder had RA more than 5 years. Autonomic dysfunction in RA patients is associated with disease activity. 77,4% of those wit h nervous disorder had DAS > 5,1, i.e. high disease activity. RA may induce neuropsychiatric disorders, affecting nervous system functions. Early detection of these disorders can prevent debilitating changes in the nervous system and improve the quality of life in patients with RA. Conclusions. The duration of the RA disease and the nerve damage are not correlated. Patients with RA history less than 5 years are more likely to develop nerve complications. Autonomic dysfunction in RA patients is associated wi th disease activity. Early detection of neuropsychiatric disorders allows prevention of debilitating changes in the nervous system.