Introduction. Multimorbidity in patients undergoing hemodialysis causes major changes in their lifestyle that affect their quality of life. In Moldova there have been no studies to prove this. Aim of the study. To examine the quality of life ( level and its correla tion with multimorbidity in patients with chronic kidney disease. Materials and methods. The participants were individuals with end stage renal failure who received hemodialysis in one outpatient clinic in Chisinau during January and February 2018. The sam ple included 30 adults; they all received hemodialysis treatment for the minimum of one month. Data was collected using a questionnaire with sociodemographic and clinical variables; it also included the SF36 questionnaire for assessing the quality of life. Multimorbidity, defined as the existence of two or more medical conditions within one person, was assessed as a simple account of diseases. Results. Of the 30 patients on hemodialysis, 17 ( were women, the mean age (M± was 47.8±15.3 years. The o nset of chronic kidney disease was 37.7±17.5 years; they started the hemodialysis at 46.1±15.6 years, with a duration of 16.23±20.5 months, with 1 to 3 procedures per week. Concomitant diseases were identified in 26 patients, and in 21 ( cases multimor bidity was established. The average total score of quality of life was found to be 62.7±12.9 (in a range 47 85) points. Scores of mental health were higher (68.6± than those of physical health (55.4± p<0.001). It was found that the increasing dur ation of hemodialysis sessions determined poorer quality of life (p< The total score of quality of life was found to be lower in participants with multimorbidity, especially in the physical domain (p< Furthermore, the number and severity of com orbid conditions correlate significantly with lower QoL (r= p<0.05) in patients with chronic kidney disease. Conclusions. Concomitant medical conditions, multimorbidity especially, have a negative impact on the quality of life in hemodialysis patients