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SM ISO690:2012 SEDAIA, Ecaterina. The effect of the metabolic syndrome on right ventricular diastolic function. In: MedEspera: International Medical Congress for Students and Young Doctors, Ed. 7th edition, 3-5 mai 2018, Chişinău. Chisinau, Republic of Moldova: 2018, 7, pp. 46-47. |
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MedEspera 7, 2018 |
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Congresul "International Medical Congress for Students and Young Doctors" 7th edition, Chişinău, Moldova, 3-5 mai 2018 | ||||||
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Pag. 46-47 | ||||||
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Introduction. The importance of right ventricle (RV) structure and function has been always underestimated by physicians in their daily practice. Diastolic function of RV generally represents a complex process and its dysfunction is associated with pressure and volume overload pathologies, primary lung disease, ischemic heart disease, left ventricle dysfunction etc. According to the last studies, metabolic syndrome(MS) also has impact on RV structure and function and represents important marker of cardiovascular risk. Aim of the study. The aim of this study was to examine the impact of MS on RV remodeling and mechanics, especially diastolic function and to determine the most important parameters of MS for right heart remodeling. Materials and methods. The study included 68 subjects: 34 subjects with MS (21 women and 13 men) and 34 controls (17 women and 17 men). There was no statistically important difference in the mean age between the subjects with MS and controls (p > 0.05). MS was defined by the presence of ≥ 3 IDF, AHA/NHLBI (2009) criteria. All subjects underwent complete two-dimensional echocardiography and laboratory blood tests. We determined the ratio of early and late diastolic tricuspid flow velocities/(E/A) and the ratio of early diastolic tricuspid and septal tricuspid annuli flow velocity (E/e’). Assessment of RV systolic or diastolic function was based on the recommendation of the European Society of Echocardiography 2015. Also anthropometric measures (height, weight, waist circumference) were taken from all the subjects included in the study.Results. Parameters of RV diastolic function indicated the RV diastolic dysfunction in patients with MS (E/A ratio 1.20±0.27 in subjects with MS and 1.30±0.33 in controls, p < 0.001; E/e’ ratio 6.50±1.43 in subjects with MS and 5.11±1.03 in controls, p < 0.001). According to multiple regression analysis systolic blood pressure (β = 0.105, P = 0.022), waist circumference (β = 0.092, P=0.031), plasma glucose level (β= 0.088, P= 0.043) showed independent association with E/e’. Conclusions. MS plays an important role in RV diastolic dysfunction. The most important parameters that provoke RV remodeling are systolic blood pressure, waist circumference and glucose level, that need special attention of the physicians due to their frequency of occurrence in general population. |
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Cuvinte-cheie metabolic syndrome, right ventricle, diastolic function |
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