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SM ISO690:2012 CRACEA (DRUŞCA), Angela, REVENCO, Ninel. Indicii sistemului antioxidant în artrita juvenilă idiopatică. In: Curierul Medical, 2012, nr. 2(326), pp. 28-33. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 2(326) / 2012 / ISSN 1875-0666 | ||||||
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Pag. 28-33 | ||||||
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The pathogenesis of juvenile idiopathic arthritis (JIA) is complex, in a permanent study. Oxidative stress has shown to play an important role in the perpetuating inflammation. The antioxidant barrier is a complicated system of enzymes, elements and substances that are formed to protect the aerobic organisms against high concentrations of oxygen. 150 children with JIA and 20 real healthy children were included in a randomized study. The authors examined the indices of the antioxidant system (total antioxidant activity (AAT), superoxiddismutase (SOD), catalase, glutathione-peroxidase, glutathionereductase and ceruloplasmin) of 90 patients with JIA and 20 healthy children. A low endogenous antioxidant capacity was found in the patients with JIA and the functional parameters of SOD, catalase, glutathione-peroxidase and glutathione-reductase were found to be much lower for the patients with JIA, compared with the control group. The values of the antioxidant indices were significantly lower in the systemic form, while glutathione-peroxidase, glutathione-reductase and ceruloplasmin were noted as having practically the same values in all evolutionary variants.
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Cuvinte-cheie Juvenile idiopathic arthritis, oxidative stress, antioxidant system |
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