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SM ISO690:2012 LAGUTA, Iryna, STAVINSKAYA, Oksana, KUZEMA, Pavlo, LUPASCU, Tudor. Hygroscopicity of the composites with various Enoxil-to-silica ratios. In: Chemistry, physics and technology of surface : Workshop "Nanostructured biocompatible / bioactive materials", 24-25 mai 2017, Kyiv. Kyiv, Ukraine: Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine, 2017, p. 96. ISBN 978-966-02-8223-0. |
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Chemistry, physics and technology of surface 2017 |
Conferința "Chemistry, physics and technology of surface"
Kyiv, Ucraina, 24-25 mai 2017
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Hygroscopicity of the composites with various Enoxil-to-silica ratios | |
Pag. 96-96 |
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Recently, much attention is focused on a study of bioactive compounds of plant origin with antibacterial and antioxidant properties. Such a kind of the compounds in a relatively novel preparation (Enoxil) was obtained by the oxidation of tannins extracted from grape seeds and it was found to possess high antibacterial and antioxidant activity. The Enoxil is a mixture of monomeric derivatives of catehine and epicatehine in the free form and esterified with gallic acid as well as with peroxidic compounds. Due to high content of hydrophilic groups, Enoxil is characterized by enhanced hygroscopicity, which, in turn, requires special conditions for its storage or inclusion in formulation preventing excess water uptake. It is known that highly dispersed silica may be used in the drug composition as a carrier of biologically active substance, which also decreases the hygroscopicity of the latter. In the previous study we did reveal a decrease in Enoxil hygroscopicity when this preparation was dispersed at silica surface. The aim of this work was to prepare the Enoxil-silica composites with various Enoxil-to-silica ratios and to examine the effect of silica content on water absorption by these composites. Fumed silica with Ssp of 300 m2g (A-300, Kalush, Ukraine) was mechanically mixed with Enoxil powder (produced at the Institute of Chemistry, Academy of Sciences of Moldova). The Enoxil-to-silica ratio was varied within 0.1’1.0 range. The capability of Enoxil, silica and Enoxil-silica composites to absorb water from the gas phase was determined gravimetrically by the sample mass change before and after holding in an exsiccator. The data on water absorption by each composite was compared to the theoretically calculated amount of water which would be absorbed by the composite in the case when individual components do not affect the water absorption by each other. For all the composites studied, the water absorption was found to be less than that for the Enoxil powder. The largest decrease in hygroscopicity was observed for the composites with Enoxil-to-silica ratio of 0.1’0.2, corresponding to the approximate Enoxil monolayer formed at silica surfаce. Thus, the approach to prepare Enoxil-silica composites was found to be suitable for decreasing the Enoxil hygroscopicity and for improvement its storage stability. Acknowledgements. The research leading to these results has received funding from the People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme FP7/2007-2013/ under REA grant agreement n° PIRSES-GA-2013-612484.
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<meta name="citation_author" content="Laguta Iryna">
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