Many pharmaceutically active compounds (PhACs) have emerged as main water pollutants, based on their toxicity against biological systems, even in concentrations of ng L-1 . Among them, carbamazepine, and clofibric acid were the most frequently detected pharmaceutical residues in wastewater effluents, surface water, groundwater, and even in drinking water. Carbamazepine is an anticonvulsant drug used primarily for the treatment of epilepsy and clofibric acid is the main pharmacologically active metabolite in pharmaceutical products used for controlling blood lipid content. Recent researches showed that filamentous bacteria (actinomycetes) are able to degrade a wide range of organic and inorganic toxic compounds due to their complex enzymatic system. Biostimulation of the metabolic activity consists in assurance of optimal cultivation conditions for microorganisms in order to induce a well metabolic functionality with positive impact in enhanced remediation process. The aim of this study was to establish the biotechnological conditions for growth in the multiple cultures of streptomycetes and activated sludge in biodegradation of carbamazepine and clofibric acid, in order to obtain the increase of yield of biodegradation. The strain Streptomyces MIUG 4.89 from Collection of Microorganisms of Bioaliment Research Platform (acronym MIUG) was recently selected, for its ability in carbamazepine and clofibric acid biodegradation, during cultivation in submerged system under aerobic controlled conditions at initial concentration of pharmaceutical compounds of 0.2 mg L-1 . The selected strain and activated sludge from the wastewater treatment plant of Galati, inoculated in a ratio of dry biomass 1:1, were able to remove carbamazepine and clofibric acid in percent of 46 % and 60%, respectively at a concentration of 0.2 mg L-1 , after 7 days in submerged cultivation with aeration and agitation on a minimal medium supplemented with 5 g L-1 glucose and 2 g L-1 urea, pH 7.4. The results demonstrate the possibility to use starter cultures and wild microorganisms in mixed association with reduced biological competition for water quality bioremediation in simple cultivation conditions similar with those from natural environments.