The hydrographic basin of the Miletin River is situated in the southeast of Europe, in a transitional temperate–continental climate, with considerable variations in the regime of precipitations. The purpose of this study is the spatial and temporal analysis of the mean seasonal discharges, meant to underline the need of implementing regulation projects for the Miletin stream. Furthermore, there are only a few specialized works on this hydrographic basin. The mean seasonal runoff presents significant seasonal and multiannual variations, caused by the high frequency of torrentiality, which characterizes the climate of the Miletin River area. Data from the rainfall stations of Nicolae Balcescu, Chiscareni, and Halceni, as well as from the hydrometric stations of Nicolae Balcescu, Sipote, and Halceni– downstream, respectively, were used. Unlike the stations with a natural runoff regime (Nicolae Balcescu, within the upper basin, Sipote within the middle basin, respectively), for Halceni–downstream (on the lower stream), the artificial runoff underlines a weak correlation with the rainfall regime. The data rows regard periods of 33–59 years, enough to conduct statistical analyses. Data from Halceni– downstream were analyzed, too, though the variables that characterize the hydrologic and rainfall regime within this region concern only 18 years. In the Miletin hydrographic basin, low and high discharge oscillations occur in all the four seasons. This characteristic is very different from those of the great hydrographic arteries that cross the east of Romania: Pruth and Siret.