Medicated jelly can be found in solid dosage forms with application in treatment of different type of diseases for children and elderly. The market offers different types of medicated jelly, like medicated jelly with calcium gluconate, metformin hydrochloride, acyclovir, alendronate, etc[1]. Betulinic acid [BA] and betulin [B] are triterpenes, both present important biological activities like anti-inflammatory, antitumor effects[2]. Betulinic acid proves over the years a good activity into induction of apoptesis and antiangiogenic response for tumor cells [3]. For the current study, we consider important to study the interactions between the most used materials in medicated jelly formulation (pectin, gelatine, etc) with betulinic acid and betulin. Thermal induces interaction for binary mixture between the most common materials used in medicated jelly formulation, betulin and betulinic acid was studied using a TG/DTG/HF and FTIR analysis (see Fig.1 and Fig. 2).figureFig. 1: FTIR spectra for betulinic acid, betulin, gelatine and for jelly. Fig.2: TG/DTG/HF curves for betulinic acid, betulin, gelatine and for jelly