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| Ultima descărcare din IBN: 2023-02-15 05:40 |
 SM ISO690:2012ŞUTA, Lenuţa-Maria, DRAGOMIRESCU, Anca, MUNTEAN, Cornelia, LEDEŢI, Adriana, VLASE, Gabriela, VLASE, Titus, BAUL, Bianca Beatrice, STELEA, Lavinia, LEDEŢI, Ionuţ. Preformulation studies for antiandrogen drug bicalutamid. In: Book of Abstracts: of the 28th Symposium on Thermal Analysis and Calorimetry – Eugen Segal – of the Commission for Thermal Analysis and Calorimetry of the Romanian Academy (CATCAR28), Ed. 28, 9-10 mai 2019, Chişinău. România, Arad: Gutenberg Univers Arad Publishing House, 2019, p. 46. ISBN 978-606-675-208-4. |
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| Book of Abstracts 2019 | ||||||
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Simpozionul "28th Symposium on Thermal Analysis and Calorimetry – Eugen Segal – of the Commission for Thermal Analysis and Calorimetry of the Romanian Academy (CATCAR28) " 28, Chişinău, Moldova, 9-10 mai 2019 | ||||||
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Bicalutamide (BCLT) is an antiandrogen medication that is primarily used to treat prostate cancer [1], but more recently as an androgen blocker of promoting feminization in male-to-female transgender adolescents [2]. BCLT derivatives are also studied for their activity as androgen receptor antagonists [3]. This study deals with the evaluation of compatibility of BCLT with several pharmaceutical excipients, using as investigational tools thermal analysis in dynamic air atmosphere (TG/DTG/HF data), FTIR spectroscopy and PXRD patterns. All samples were prepared in 1:1 mass ratio and kept in closed vials under ambient conditions. A comparative discussion for binary mixtures vs. each excipient and the evaluation of thermal treatment for inducing interactions is carried out. |
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