Predictive assessment of the human and environmental toxicity of chemical substances

Schüürmann Gerrit

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SCHÜÜRMANN, Gerrit. Predictive assessment of the human and environmental toxicity of chemical substances. In: Ecological and environmental chemistry : - 2017, Ed. 6, 2-3 martie 2017, Chișinău. Chisinau, Republic of Moldova: Academy of Sciences of Moldova, 2017, Ediția 6, p. 51.

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Ecological and environmental chemistry
Ediția 6, 2017

Conferința "Ecological and environmental chemistry 2017"
6, Chișinău, Moldova, 2-3 martie 2017

Predictive assessment of the human and environmental toxicity of chemical substances

Pag. 51-51

Schüürmann Gerrit¹²

¹ Helmholtz Centre for Environmental Research GmbH – UFZ,
² Technical University Bergakademie Freiberg

Disponibil în IBN: 6 martie 2019

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Through the European Directive REACH in 2007, alternative methods have gained increased importance as non-animal tools for the toxicological assessment of chemical compounds. In this context, the 3R principle of reducing, refining and replacing animal testing has resulted in a paradigm shift toward integrated testing strategies (ITS) that aim at exploiting the combined information generated from several non-animal methods in order to – partly or fully – replace a given animal experiment. In the presentation, respective non-test (in silico) and test (in chemico, in vitro) methods are outlined for industrial chemicals and pharmaceuticals, focussing on chemoassays,1 read-across,2 structural alerts,3 computational chemistry,4 and chemoavailability5 for predicting reactive toxicity and metabolic acti-vation through P450 catalysis.

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