Background: The biologically active compounds - new Schiff bases and their coordinative compounds (CC) with [3d] metals exhibit pronounced antiproliferative and cytotoxic properties, exceeding tens and hundreds of times antitumor activity of doxorubicin [Gulea A., et al., 2007, 2009], but their action on normal tissues is insufficient studied. The aim of research was to study the peculiarities of the influence of the new non-platinum metal CC – CMA-18, CMA-34, CMG-41, MG-22, TIA-123 and TIA160 on the intensity of the oxidative stress in the blood serum of the experimental animals under physiological conditions. Methods: Biological activity of the CC, was evaluated in experiments on a group of 50 male rats Wistar line, randomly divided into 7 groups. The first group – control (sham), were injected i/m saline solution daily for 30 days. The experimental animals from groups 2 - 7 were administered i/m 10 μmol/kg the studied BAC CMA-18, CMA-34, CMG-41, MG-22, TIA-123 and TIA-160 three times a week for 30 days. The amount of the serum oxidative stress markers ‒ malonic dialdehyde (MDA), nitric oxides metabolites NO2+NO3, the ischemia-modified albumin (IMA), advanced glycated end products (AGE), and advanced oxidative protein products (AOPP) was determined. Results: The study revealed that the level of the MDA is basically maintained at the normal levels by CMG-41, MG-22 and TIA-123, and the most of the studied CC induced just a discrete increase tendency, which denotes the pro-oxidative effect of the tested compounds at the final stages of lipid peroxidation. AOPP changes due to the influence of the tested compounds have been shown to be of no statistical relevance. The content of nitric oxides metabolites NO2+NO3 practically remained at the level of intact animals. The study revealed that the AGE content decreased statistically conclusive by 18%-22% after the administration of TIA-160, CMG-41 and MG-22. The tested CC did not influence conclusive the levels of IMA, except MG-22, that produced a veritable statistical increase of the IMA and CMA-18 decreased its content compared with the control. Conclusions: The influence of the tested CC on the studied indices of the oxidative stress is selective. This selectivity can be the foundation of their particular strong antiproliferative and cytotoxic selective action upon the tumor cells, but not only on healthy ones. Further studies are needed to investigate the structural features in relation to their biological activity.