The modern business environment is characterized by high urgency and uncertainty. The complexity of the operation of enterprises is exacerbated by the situation caused by the Pandemic. In this difficult time, information technology is increasingly penetrating into business and becoming a means and a way of existence. The pervasive impact of information technology, the emergence of artificial intelligence, the impact of Big Data - all of this is fundamentally changing the way businesses operate. Klaus Schwab calls this global process of transition Industrialization 4.0. This process has a serious impact on the SME sector in the Republic of Moldova. The importance of this sector for the economy of Moldova is extremely high, therefore, ensuring the normal functioning of such enterprises in the new conditions is a task of state importance. The impact of transformational changes on the small and medium-sized enterprise sector will be discussed in this article.