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SM ISO690:2012 BURUIANA, Sanda, MAZUR, Minodora, ROBU, Maria, TOMACINSCHII, Victor, MAZUR-NICORICI, Lucia. Hemostasis of patients with non-Hodgkin lymphoma and anticardiolipinic antibodies. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 129. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Pag. 129-129 | ||||||
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Rezumat | ||||||
Background. Anticardiolipin antibodies are autoantibodies that erroneously recognize cardiolipins on the outside of cell membranes, causing hemostasis disorders, which affect the therapeutic conduct, effectiveness of treatment and quality of life of patients with malignant lymphoma. Objective of the study. Evaluation of patients' hemostasis according to the morphological type of NHL, disease stage and tumor size. Material and Methods. The study included 83 newly patients (men-34, women-49) with a mean age of 63.2 years, with NHL, investigated complex, by research of lupus anticoagulant (LA) by Turbidimetry; aCL antibodies, antiβ2glycoprotein I IgG, IgM by ELISA method. Hemostasis disorders were evaluated according to the morphological type of NHL, stage, tumor size. Results. aCL were detected in 10 (12%) patients with advanced stage B cell NHL in 60%, mean age 52.8 years. LA was present in 80% of cases, unlike aCL IgG antibodies and 10% IgG antiβ2glycoprotein I. Hemostasis disorders were found in 6 (60%) patients: thrombosis-at 4 (40%) with NHL in the cells of the mantle area, lymphocyte from small lymphocytes, lymphoblastic in 75% local stage (I and II), but with a large tumor component (> 11 cm), and hemorrhage at 2 (20%) with stage IV small lymphocyte lymphoma, in which immune thrombocytopenia developed. Conclusion. The presence of lupus anticoagulant, advanced age, generalized stage, and large tumor size are risk factors for the development of hemostasis changes in NHL patients, especially thromboembolic events. |
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Cuvinte-cheie anticardiolipin antibodies, thrombosis, Hemorrhage, lymphoma, anticorpi anticardiolipinici, tromboze, hemoragie, limfom |
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