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Ultima descărcare din IBN: 2023-07-17 16:58 |
SM ISO690:2012 BOUR, Cristina, RYVNYAK, V.. Age related histological changes of the pineal gland. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 13. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Background. More and more information is accumulating about the role of the pineal gland in the regulation of the body's circadian rhythms. About 50% of the population suffers from age-related disorders of fat-carbohydrate metabolism, circadian rhythms, which affects the quality and life expectancy. Objective of the study. The purpose of this work is to review, analyze and structure information, based on the literature of the last years, on the topic of age-related changes in the histological structure of the pineal gland and their effect on the body. Material and Methods. A retrospective analysis of studies perfomed on 2772 pediatric and adult autopsy cases. The glands have been processed for histological analysis and immunohistochemical staining with glial fibrillary acidic protein (GFAP). Slides were assessed under polarized light and digitally scanned. Results. Three age groups were included in the study: 0–25, 46–65, and 66–96 years of age. In the 0-25 age group, the main architectural type was cellular, in the 45-65 group was trabecular and in 66-96 year group was alveolar. The mean percentage of pineal calcification was 15% of the gland, peaking within the 66–96 age group. Glial cysts were found in 20.8% of cases. The intensity of GFAP stain was maximal in the pediatric age group, but the extent of glial tissue was much larger in elderly patients. Conclusion. The main histological changes include thickening of the capsule due to proliferation of connective tissue, replacement of the normal secretory parenchyma of gland with glial tissue, connective tissue, calcifications, glial cysts and, consequently, decreased melatonin synthesis. |
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Cuvinte-cheie pineal gland, calcifications, melatonin, cyst., glanda pineală, calcificări, melatonină, chist |
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