The aim of this work is the synthesis, determination of the composition, structure, physicochemical and biological properties of manganese, iron, cobalt, nickel, and copper coordination compounds with N’-[(3- methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-yl)(phenyl)methylidene]benzohydrazide (H2L). Hydrazone H2L was synthesized by interaction of ethanolic solutions of benzohydrazide and 4-benzoyl-5-methyl-2-phenyl- 2,4-dihydro-3H-pyrazol-3-one. Its composition and structure were determined using 1H and 13C NMR spectroscopy. Chlorides, bromides, perchlorates, and acetates of stated above metals react with H2L forming coordination compounds of the following

composition: (Cu(HL)X·nC2H5OH, X = (Cl- ,Br-, ClO4
-; n =0,1), Cu(HL) ·H2O, M(HL)2 (M = Mn2+, Ni2+),
M(HL)2X (M = Co3+, Fe3+; X = Cl-, NO3
-).
The antimicrobial activity of these compounds was studied in vitro using the method of two-fold serial
dilutions in liquid nutrient medium. The antimicrobial activity was tested on standard strains of grampositive
(Staphylococcus aureus), gram-negative (Escherihia coli) microorganisms, Candida albicans
and Criptococcus neoformans. It was determined that the synthesized coordination compounds manifest
selective bacteriostatic and bactericide activity towards both gram-positive and gram-negative
microorganisms in the range of concentrations 0.016-0.125 mg / mL. The experiment showed that the
nature of the central atom and acid residue have the main influence on the minimal inhibitory (MIC) and
bactericidal (MBC) concentrations of the studied coordination compounds. For the homotypic
coordination compounds MICs and MBCs change in the following way: Cu2+ < Ni2+ ≤ Сo3+ < Fe=Mn2+and Cl- = Br- < ClO4
-.
This work was fulfilled with the financial support of the Project 18.80.07.17A/PS
of the State Program.