Medicinal plants, especially those of spontaneous phlora are the source of a large number of bioactive substances essential in medicine and phytotherapy. Using native plants, is of economic importance for Moldova, which flora contains a significant diversity of taxa that can be used in the fight against cardiovascular diseases, infections, cancer, etc. To achieve the full exploitation of plant resources in general, especially for medicinal plants, there shold be takien steps for studying and describing different species in the country. Historically a series of descriptive methods have been developed to study plant. The first results came into effect of systematization by Carl von Linne. Today this method is irrational. With the development of research methods of the tissue, cellular, biochemical and the molecular, various data on the variability of the specific population and individual plant were obtained. But so far in our country Botany as classical biological science is the main source for such studies and no studies flora develops methodological improvement. As a result, other scientific areas are on the forefront, providing a much higher resolution research. To take into account the complexity of spontaneous flora investigating issues with her recovery, it is imperative to exploit the following: description of the botanical description biogeographical, molecular and biochemical analyzes. All thes are complemented with the application of modern technologies offered by Geoinformatics, Bioinformatics and Chemoinformatics. The information provided by such studies can be analyzed in complex, representing an appreciation of biodiversity across countries, assessing their potential pharmacological opportunities for the selection and application of biotechnology in medicinal plants and forecasting of economic effect of producing and marketing preparations health. In this context, information required to analyze complex exploitation of medicinal plants in Republic of Moldova. Application of modern research techniques offer rapid implementation of new crop species for their further improvement and application in biotechnology valuable qualities in terms of content and quality chemistries. In this context, molecular biology provides not only information about the taxonomic affiliation or inter- and intraspecific polymorphism, and effective monitoring tools to improve the species. Multilateral nature of scientific activity should result in the creation and development of databases and online public services to store data, information and results in an organized and systematic investigations, and also for the extraction and implementation in research. Thus, it is possible to store in the database of the genome and studied protein structures identified, the gene expression data in these so. Data on the chemical structure identified medicinal plants, their structure and variability can be stored in Chemoinformatic resources. The complex, these resources provide information on the biosynthetic pathways leading to certain chemical compounds and genetic mechanisms regulating these pathways to stimulate the production of biologically active compounds targeted.