In a long field stationary experiment on typical black soil of the Left-Bank Forest-Steppe of Ukraine, the effect of the fertilizer system on agrochemical indicators was studied. The quantitative parameters of the qualitative changes of these indicators are determined for the mineral, organo-mineral and organic fertilizer systems. It was found that the parameters of agrochemical indicators change to a greater extent in time than from the implemented fertilizer system. For a 28-year period of research, sharp fluctuations in the exchange acidity have not been established, although there is a tendency to a decrease in pHKCl with an increase in the rate of mineral fertilizers. The degree of saturation of the bases remains at a very high level - 94.5–98.3%, where exchangeable calcium prevails in the structure of absorbed bases — more than 325.4 mg/kg of soil. The systematic application of fertilizers contributes to a significant increase in the content of metabolic potassium to 8.7 mg/kg of soil, the content of mobile phosphorus to 292.8 mg/kg of soil and mobile potassium to 263.5 mg/kg of soil with an organomineral fertilizer system.