Among the methods of thin nanocomposite polymer-based coating deposition the method of active gas phase generation as a result of exposure of the polymer in a vacuum by concentrated flow of electrons, ions, laser radiation and subsequent deposition of volatile particles on the surface has special scientific and practical interest [1–3].   The occurring processes are highly chemical activity of disperse volatile products and introduction the vapor fillers to their structure allows to form nanocomposite layers with different composition.  Thus, depending on the conditions of dispersing the deposition process of polymer layer can be carried out by aerosol or adsorption-polymerization mechanisms [2].   The analysis of morphological and orientation effects occurring in nanoscale layers, their dependence on the mode of the active gas phase generation, deposition conditions was carried out.  The increase in the rate of coatings growth, the reduction of adsorbed dispersion products polymerization degree on the activated surface and the influence of the filler nature (metal nanoparticles, polymers) on the morphology, self-organization processes and molecular architecture of composite polymer-based coatings were explained as part of the proposed adsorptionpolymerization mechanism [2].   The effectiveness influence of the parameters and conditions of the active gas phase generation via electron beam (energy and the electron flux density, the introduction in a target of low-molecular compounds, the laser assisting of the dispersion process, the plasma discharge in volatile products) on the deposition kinetics, the molecular structure and properties of polymer-based coatings was determined.   The methods of conductivity and a sensing properties control of conductive polymer-based coatings in the deposition stage were proposed. The effect of composition and structure on the antimicrobial properties of composite polymers-based coatings with antimicrobial drugs and silver nanoclusters was studied. The main parameters of bactericidal effect, the availability and efficiency of synthesis from the active gas phase generated by the electron beam dispersion for creation a biocompatible thin film systems with controlled release of medicinal drugs were established [3].