In recent years, there has been growing interest in the development and widespread use of membrane technologies in the purification of natural and wastewaters, as well as in the food industry, biotechnology, and separation. This is largely made possible by the creation of high-performance and relatively inexpensive polymeric membranes. However, ceramic membranes have several advantages: resistance to high temperatures and chemically aggressive media, high mechanical strength, long life. The physical-chemical regularities of preparation a macroporous ceramic and multilayered ceramic materials based on natural silicon dioxide – quartz sand of Belarus, Qatar, Saudi Arabia, Mongolia, Azerbaijan, Turkmenistan and Vietnam were studied. It was shown that the properties and structure of large-pore ceramic substrates are mainly determined by the phase composition and the content of quartz in natural sand. The membrane layers on the surface of macroporous ceramics were formed by application of a suspension of fine natural silicon dioxide in an aqueous solution of aluminosilicate binder. The obtained microfiltration membranes with an average pore size of 3-5 μm, a coefficient of air permeability 10-12-10-13 m2, with capacity for water of 10-50 m3/(h×m2×bar) and tensile strength up to 10 bar are promising for wide practical use in the processes of microfiltration of liquid media.