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SM ISO690:2012 RÎVNEAC, Elena, TAGADIUC, Olga, RYVNYAK, V., GUDUMAK, V., ANDRONACHE, Lilia, SARDARI, Veronica. Cathepsin D Activity in Experimental Liver Chirrosis and After the Administration of Copper Coordination Compounds and Bacterian Remedy BioR. In: Curierul Medical, 2011, nr. 3(321), pp. 17-21. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 3(321) / 2011 / ISSN 1875-0666 | ||||||
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Pag. 17-21 | ||||||
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This paper investigates the influence of the copper coordination compounds CMT-28, CMT-67 and of the bacterial remedy BioR on the cathepsin
D activity in liver in experimental cirrhosis. The activity of cathepsin D was also detected electron-histochemicaly in the liver during the regression
of experimental hepatic cirrhosis. The result suggests that the coordinative compound CMT-67 used in combination with the bacterial remedy BioR
has a pronounced stimulating effect on the enzymatic hydrolysis of the extracellular matrix under the action of cathepsin D and contributes to a more
efficient breakdown of the excessive fibrous tissue in liver. It was determined that the active cathepsin D is localized intracellularly in the lysosomes of
hepatocytes, macrophages, fibroblasts and endothelial cells, as well as extracellularly on the collagen fibrils near the parenchymal and mezenchymal cells.
In addition to its participation in the intracellular proteolysis, cathepsin D is secreted by the hepatocytes and connective tissue cells to the extra-cellular
space and participates in the extracellular breakdown of the fibrous tissue. |
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Cuvinte-cheie cathepsin D, liver cirrhosis, coordinative compounds of cuprum, bacterial remedy BioR. |
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