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Ultima descărcare din IBN: 2024-03-18 12:26 |
SM ISO690:2012 MAZURU, Vitalie. Rolul pivotal al macrofagelor în progresia tumorală. In: Curierul Medical, 2010, nr. 4(316), pp. 52-61. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 4(316) / 2010 / ISSN 1875-0666 | ||||||
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Pag. 52-61 | ||||||
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Clinical and experimental evidence have shown that macrophages (TAM) are the main component of the leukocyte infiltrate supporting
tumor growth. Over the years the mechanisms that support the tumor growth have become increasingly clear and in several experimental
tumor models, the activation of an inflammatory response mediated by macrophages has been shown to play an essential role for full neoplastic
transformation and progression. TAMs are derived from peripheral blood monocytes recruited into the tumor. Upon being activated by cancer
cells, TAMs can release a vast diversity of growth factors, proteolytic enzymes, cytokines and inflammatory mediators. Many of these agents are
key factors in cancer progression. The presence of extensive TAM infiltration has been shown to correlate with poor prognosis in a variety of
human carcinomas. TAMs promote cancer progression through several mechanisms including the growth of tumor cells, tumor angiogenesis and
lymphangiogenesis, matrix remodeling, tumor cell migration and invasion. There are complex paracrine-signaling networks between TAMs and
cancer cells to activate each other. This evidence strongly supports the idea that TAMs are one of the most important players in the inflammatory
networks expressed in the tumor microenvironment, and it suggests these cells as possible targets of anticancer therapies. |
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Cuvinte-cheie macrophages, tumor growth, metastasis, angiogenesis, tumoral microenvironment |
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