Background: In all the patients with combustions comprising more than 50% of the body surface, bacteremia takes place, and, during the shock period, its influence is minimal, then, during the toxemia period, when the autolysis process occurs in the affected area, microflora presents a particular danger. Microflora manifests its virulence completely depending on the state of the local and general immunity, which, in its turn, differs in different climatic conditions. Therefore, in order to determine the effective treatment, it is very necessary to study the microflora in patients with combustions in different diametrically opposed climatic conditions – tropical and continental. Material and methods: The investigations were performed in 287 patients with combustions in tropical conditions (Cuba) and in 133 patients with combustions in continental conditions (Moldova, Moscow) in order to determine the role of microflora in the evolution of combustions in different climatic conditions. The following factors were determined: the microbial type, the sensibility degree to antibiotics, the conditions of favoring microbial invasion and the role of the medical staff in favoring patients with combustions affected by the microbial invasion. Results: The obtained results showed that the conditions of the tropical climate are very favorable for microflora evolution, and the medical staff plays a very important role in favoring the microbial invasion, in the assessment of septicemia and also in the assessment of the microbial invasions in the pathogenesis of the combustion wounds. Conclusions: Microflora presents a very big danger in the evolution of combustions. The virulence of microflora in the conditions of the tropical climate is much higher compared to the conditions of the continental climate. The medical staff and the necessary conditions for preserving the asepsis and antisepsis play a very important role in avoiding the microbial invasion in patients with combustions, both locally, and generally.