In the case of “typical” ischemic strokes, a patient experiences sudden onset of symptoms such as facial asymmetry, weakness of the arms, and speech disorders (FAST). Two scenarios must be considered: a false positive “mime” and a false negative “chameleon”. Stroke may occur atypically and may not be immediately recognized. Stroke mimicry ‑30% of probable stroke admissions. Stroke mimics: Todd’s paresis, complicated migraines, functional or conversion neurological disorders, subarachnoid hemorrhage, hypoglycemia / hyperglycemia / severe, hyponatremia / metabolic encephalopathy, hypertensive encephalopathy / PRES, peripheral vertigo, Guillain Barre, myasthenia gravis abscess, encephalitis, syncope, sepsis. The most common chameleons identified were: altered mental state / toxic metabolic encephalopathy, syncope, hypertensive emergency, systemic infection / sepsis, dementia. The problem of chameleons is more serious than that of mimics, because patients are not identified in time and are not treated properly. Physicians should consider the pathologies mentioned above for proper management.