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SM ISO690:2012 ZAKROYEVA, Alla, LESNYAK, Olga, KAZAK, Viktor, GROPPA, Liliana, RUSSU, Eugen, CHIŞLARI, Lia, ROTARU, Larisa, JOHANSSON, Helena, HARVEY, Nicholas C.W., MCCLOSKEY , Eugene V., LORENTZON, Mattias, KANIS, John A.. Epidemiology of osteoporotic fracture in Moldova and development of a countryspecific frax model. In: World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases, 2-5 aprilie 2020, Barcelona. Springer Link, 2021, Vol.31, Supl.1, p. 121. 10.1007/s00198-020-05696-3 |
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World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases Vol.31, Supl.1, 2021 |
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Conferința "World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases" Barcelona, Spania, 2-5 aprilie 2020 | |
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Pag. 121-121 | |
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Objective: This study describes the epidemiology of osteoporotic fractures in Republic of Moldova that was used to develop the countryspecific fracture prediction FRAX® tool. Methods: We carried out a retrospective population-based survey in 2 regions of Republic of Moldova (Anenii Noi district and Orhei district) representing approximately 6% of the country’s population. We identified hip, forearm and humerus fractures in 2011 and 2012 from hospital registers and primary care sources. Age- and sex-specific incidence of hip fracture and national mortality rates were incorporated into a FRAX model for Moldova. Fracture probabilities were compared with those from neighboring countries having FRAX models. Results: The incidence of hip fracture applied nationally suggested that the estimated number of hip fractures nationwide in persons over the age of 50 y for 2015 was 3911 and is predicted to increase by 60% to 6492 in 2050. Hip fracture incidence was a good predictor of forearm and humeral fractures. FRAX-based probabilities were higher in Moldova than neighboring countries (Ukraine and Romania). The remaining lifetime probability of a hip fracture from the age of 50 y was 5.8% in women and 4.2% in men. These probabilities were similar to those in Romania (7.0 and 3.8%, respectively) but markedly lower than those in Sweden (25.6 and 11.0%, respectively). Conclusion: The FRAX model should enhance accuracy of determining fracture probability among the Moldavian population and help guide decisions about treatment. |
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