Introduction. Chronic pain and multimorbidity are common among stroke survivors and can negatively impact their functional outcomes and independence. The aim of the study was to investigate the frequency of chronic pain and multimorbidity in post-stroke patients, and their relationships with functional independence. Material and methods. A database of 270 post-stroke patients consecutively enrolled in rehabilitation programs was used. We recorded demographic data, the number of comorbidities, presence of pain, its intensity and localization, the number of pain regions, and the patient’s functional independence. Nordic Musculoskeletal Questionnaire, Visual Analog Scale (VAS) Scale, and Barthel Index were used for this purpose. The statistical analysis was made with SPSS version 24, including descriptive statistics and correlation. Results. We revealed a mean number of 3.6 comorbidities, and 60% of patients reported the presence of pain (42% chronic and 18% acute pain). Themusculoskeletal pain was the most common type of pain (48.7%), followed by mixed (28.3%) and neuropathic pain (23.0%). A positive correlation between age and the number of painful regions (r=0.366, p<0.001), as well as the number of comorbidities (r=0.520, p<0.001) was registered. We found negative correlations with functional independence (age: r= – 0.467, p<0.001; number of pain regions: r= – 0.227, p=0.016; number of comorbidities: r= – 0.552, p[removed]