Gout and renal dysfunction
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ROTARU, Larisa, GROPPA, Liliana, CEBAN, Emil, RUSSU, Eugen, PASCAL, Rodica, SASU, Dorian, CORNEA, Cornelia. Gout and renal dysfunction. In: Archives of the Balkan Medical Union, 2023, vol. 58, pp. 382-387. ISSN 1584-9244. DOI: https://doi.org/10.31688/ABMU.2023.58.4.10
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Archives of the Balkan Medical Union
Volumul 58 / 2023 / ISSN 1584-9244

Gout and renal dysfunction

DOI:https://doi.org/10.31688/ABMU.2023.58.4.10

Pag. 382-387

Rotaru Larisa1, Groppa Liliana1, Ceban Emil1, Russu Eugen1, Pascal Rodica1, Sasu Dorian1, Cornea Cornelia2
 
1 ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
2 Timofei Moșneaga Republican Clinical Hospital
 
 
Disponibil în IBN: 19 februarie 2024


Rezumat

Introduction. The frequency of nephrolithiasis positively correlates with the degree of hyperuricemia. The objective of the study was the analysis of renal dysfunction in patients with gout from different age groups. Material and methods. 237 patients with gout (mean age for males 60 ± 8.0 years and females 63 ± 9.0 years) were examined and analyzed retrospectively. The diagnosis of gout was carried out according to the classification criteria for gout of the American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR) 2015. The patients were separated into two groups, depending on the age at gout onset: the age at onset up to and including 59 years (group I, 91 people) and the age at onset after 60 years, inclusive (group II, 146 people). The raw data was processed in SPSS version 26.0. Results. The renal function was mostly preserved in patients from group I: 51% had a level of glomerular filtration rate (GFR) corresponding to stage 2 chronic kidney disease (CKD) (in the presence of kidney damage), stage 4 CKD was determined in only 2 patients from group I. A pronounced decrease in kidney function was determined in group II, significantly more often there was stage 3 CKD (16 (22%) in group I and 59 (46%) in group II, p = 0.001). In 12 participants in group II, GFR was below 29 ml/min/1.73 m2. Only in 6% of cases, a slight decrease in GFR was determined, which was 4 times lower than in group I. Conclusions. With increasing age, the frequency of risk factors for gout increases, especially for people with kidney damage: taking small doses of acetylsalicylic acid increases the risk from 6 to 40%, diuretics from 18 to 44%, alcohol consumption from 14 to 28%, hypertension from 44 to 78%, consumption of foods saturated with purine from 51 to 68%, overweightness and obesity from 58 to 76%. 

Cuvinte-cheie
diuretics, gout, renal dysfunction, risk factors, uric acid