Introduction. Medicinal plants may contain various active substances that, when penetrating the placental barrier, may have potential teratogenic, toxic and delayed risks and effects on the fetus. The consequences of the interaction of biologically active substances of medicinal plants with psychotropic effects in human body could have many negative effects. These risks may be more unpredictable during pregnancy and lactation in patients with mental problems. Methods. The methodology represents bibliographic synthesis of evidence-based scientific publications related to the use of medicinal plants with psychotropic effects during pregnancy and lactation. Results and discussions. Patients often use herbal medicines to reduce depression, anxiety, sleep disorders and psychosomatic problems. Medicinal plants with anti-anxiety, antidepressant, hypnotic effects such as St. John's wort, valerian, passionflower, chamomile, peppermint, lemon balm, lavender, under various forms in combination with psychotropic drugs increases the potential risks during pregnancy and lactation. Conclusions. Many medicinal plants with psychotropic effects can lead to clinical, biochemical and even genomic changes, influence drug interaction and plasma concentration of psychotropic drugs.