Introduction. Retroperitoneal sarcomas (RPS) are a group of malignant tumours (PRT), arising in the retroperitoneal space and do not belong to an organ. RPS represent approximately 15.0% of all sarcomas in the human body. Caused by the vastity of retroperitoneal space and uncommon clinical behaviour, RPS is diagnosticated late, clinical manifestations being caused by the compression or involvement of near organs. Although retroperitoneal tumours are easily detectable, due to their large size, the definitive diagnosis is based on the histopathological, immunohistochemical and immuno-genetic examination. Material and methods. We conducted a transversal stady based on 118 adult patients with retroperitoneal tumours treated in Oncological Institute of Moldova between 2015 and 2020. All cases were reviewed by an expert pathologist. Results. From the total of 118 patients with retroperitoneal tumours included in the study, 84 were proved to be primitive tumours, 46(54.76%) of which were sarcomas. The most common histological subtype of sarcoma was: liposarcoma in 20 cases (23.80%), followed by undifferentiated pleomorphic sarcoma - 6 cases (7.14%) and leiomyosarcoma - 4 cases (4.76%). The average size of the tumor was 16.25 cm (±9.014 cm), Me=14.0 cm. Radical surgical treatment was performed in 31 cases (67.39%), in the other 15 cases (32.60%), cytoreductive excision or open tumour biopsy was performed. Conclusions. Surgical treatment remains the main treatment method with curative potential for retroperitoneal sarcomas. The possibility of excision a tumours with negative margins are one of the most important prognostic factors related to survival.