Introduction. Periodontal disease (PD) continues to be a challenge for the dentist, because in terms of treatment it is one of the most complicated pathologies (in this case periodontitis) and must be viewed in the complex, and therapeutic methods also need to be complex and maximally individualized. The modern concept of the approach to PD with an important role in the curative-prophylactic process confirms once again, that PD can be diagnosed, treated and monitored ("Controlled periodontitis") only by applying the principle of multilateralism. Therefore, the periodontal treatment, with the ultimate goal of rehabilitating the functions of the dento-maxillary apparatus, must be a complex, interdisciplinary one, intersecting all dental specialties, and general medicine specialists depending on the case, it needs to be staged and fully realized, thus ensuring a stable and time lasting periodontal health. Material and methods. In this study, were enrolled, 23 patients with severe periodontitis, stage III and IV, grade A – 6 patients; grade B - 10; grade C - 7 patients/ compromised in terms of the functionality of the dento-maxillary apparatus (mastication, aesthetics, phonation, deglutition, sensitivity, including psycho-emotional status), women – 14, men – 9. All patients were examined and treated in complex and maximally individualized for each clinical situation, applying the principle of multilateralism/ interdisciplinary. Results. Following the realization of the complex treatment plan (initial/ etiological stage with all components, corrective stage and maintenance treatment, consultation of general medicine specialists depending on the case), the patients in the study were rehabilitated from a morpho-functional, aesthetic and psychoemotionally aspects, thus being socially integrated. Conclusions. In terms of diagnosis, the approach to PD (in this case periodontitis) needs to be complex and multilateral/interdisciplinary. Structuring and execution of the treatment plan must be complex and complete. Giving the patient with a compromised periodontal status a new chance for morpho-functional rehabilitation of the dento-maxillary apparatus, psycho-emotional and social reintegration.