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616.831-036.1-085 (1) |
Neurologie. Neuropatologie. Sistem nervos (971) |
SM ISO690:2012 COSTRU-TAŞNIC, Elena, GAVRILIUC, Mihail, MANOLE, Elena. Previous statins use and the risk for haemorrhagic transformation in acute ischemic stroke patients. In: European Journal of Neurology, 2023, vol. 30, supl. nr. 1, p. 349. ISSN 1351-5101. |
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European Journal of Neurology | ||||||
Volumul 30, Supliment nr. 1 / 2023 / ISSN 1351-5101 /ISSNe 1468-1331 | ||||||
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CZU: 616.831-036.1-085 | ||||||
Pag. 349-349 | ||||||
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Background and aims: According metanalysis studies, long term statin use can slightly increase the risk for intracerebral haemorrhage, including haemorrhagic transformation (HT) of ischemic stroke. The aim of our study was to evaluate the risk for HT in acute ischemic stroke (AIS) patients with previous statin use and the correlation with the patients’ outcome and recovery. Methods: In a prospective, consecutive way, we’ve included patients with AIS admitted to a tertiary neurological hospital from 2018 to 2022, to evaluate possible risk factors for HT and its’ impact on discharge and 3 months follow-up status by the modified Rankin Scale (mRS). The patients were grouped, based on the HT presence, into 2 cohorts: active group (with HT) and control group (without HT). Results: From 150 patients, 55 patients presented HT during the hospitalization. The mean LDL-cholesterol level was 3.3±0.07 mmol with similar values in the compared groups (p=0.99). Up to 50% of the analysed patients presented very high cardiovascular risk prior stroke. Only 8.7% (13/150 patients) were taking high dosage statins with slightly more patients in the active cohort (11% vs 7.4%, p=0.55). The correlation analysis revealed that previous statin use didn’t significantly increase the rate of HT (OR=1.62, 95% CI: 0.43-6.13, p=0.46), didn’t influence the discharge mRS score (OR=0.37, 95% CI: 0.08-2.67, p=0.25), and the follow-up mRS: OR=0.46, 95% CI: 0.12.41, p=0.32. Conclusion: In our study the previous statin use didn’t increase the risk for HT, neither influenced the discharge or follow-up neurological functional |
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