Background: postoperative back and radicular pain is common symptoms after discectomy. The cause is multifactorial which include persistent inflammation of soft tissue, traumatic injury during surgery. This delay hospital discharge and resumption of normal activity. Controversies still exist regarding the benefits of these drugs. The aim of this study is to evaluate the outcome, neurologic impairment and safety of epidural steroids following lumbar MID. We randomized 324 patients after lumbar minimal invasive discectomy (MID) which received epidural methylprednisolone before closing the wound or none. Here we report a 2-year followup of a randomized trial of epidural steroid following lumbar discectomy. Method: a total of 324 patients undergoing MID were allocated to receive epidural methylprednisolone or none. The period of randomization was 2013-2015 and all surgeries was performed by the same neurosurgical team. Control group (87 males and 73 females) 62-l5, 74-l4, 24-l3 discectomies were performed. Methylprednisolone group (97 males and 67 females) 67-l5, 81l4, and 16-l3 discectomies. all patients received preoperative antibiotics and the same multimodal pain treatment. postoperative back and radicular pain intensity was assessed by a visual analogue scale before and at 24,48,72 and 96 hours after surgery. Results: Hospital stay was reduced from 4 to 3 days and the number of patients with neurologic signs were reduced more (69%vs45%). Incidence of reoperation at 2 years was 8% in the control group and 7% in the intervention group. No infections were registered. Conclusion: application of epidural methylprednisolone makes the recovery after MID faster and with less pain without apparent side effects.