Background: Endometrial cancer is highly relevant in the context in which it is the most common invasive malignant tumor of the female genital system, it is the fourth most common type of cancer among women, accounting for 95% of tumors that occur at the endometrial level. Material and methods: Twenty-two women with different uterine tumors were taken into account. The size, location, mass characteristics, and correlation with surrounding tissues were correlated with histological results. Results: The reproducibility of the tumors are compromised by different factors that affect the diagnosis quality and respectively it can affect treatment and management of patients. Conclusions: It is necessary to develop unic criteria of specimens manipulation.