Novel one-pot multicomponent strategy for the synthesis of pyrrolo[1,2-a]benzimidazole and pyrrolo[1,2-a]quinoxaline derivatives
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GEORGESCU, Emilian I., NICOLESCU, Alina Florica, GEORGESCU, Florentina, SHOVA, Sergiu, TEODORESCU, Florina Ruxandra, MACSIM, Ana-Maria, DELEANU, Călin. Novel one-pot multicomponent strategy for the synthesis of pyrrolo[1,2-a]benzimidazole and pyrrolo[1,2-a]quinoxaline derivatives. In: Synthesis (Germany), 2015, vol. 47, pp. 1643-1655. ISSN 0039-7881. DOI: https://doi.org/10.1055/s-0034-1380185
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Synthesis (Germany)
Volumul 47 / 2015 / ISSN 0039-7881

Novel one-pot multicomponent strategy for the synthesis of pyrrolo[1,2-a]benzimidazole and pyrrolo[1,2-a]quinoxaline derivatives

DOI:https://doi.org/10.1055/s-0034-1380185

Pag. 1643-1655

Georgescu Emilian I.1, Nicolescu Alina Florica23, Georgescu Florentina4, Shova Sergiu35, Teodorescu Florina Ruxandra2, Macsim Ana-Maria3, Deleanu Călin32
 
1 Centrul de Cercetare Oltchim, Ramnicu Valcea,
2 "C.D. Nenitzescu" Centre of Organic Chemistry, Romanian Academy,
3 “Petru Poni” Institute of Macromolecular Chemistry,
4 Teso Spec SRL,
5 Institute of Chemistry of the Academy of Sciences of Moldova
 
 
Disponibil în IBN: 2 iunie 2023


Rezumat

Abstract A simple one-pot multicomponent procedure has been developed for the synthesis of pyrrolo[1,2-a]benzimidazole and pyrrolo[1,2-a]quinoxaline derivatives by heating a 1:2:1 molar mixture of a benzimidazole unsubstituted on the imidazole ring, a 2-bromoacetophenone derivative, and a nonsymmetrical activated alkyne in refluxing 2-ethyloxirane. The reaction can be performed under conventional reflux conditions or with microwave irradiation. 

Cuvinte-cheie
cycloadditions, fused-ring systems, heterocycles, multicomponent reactions, Ylides