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 SM ISO690:2012RAJABI, Mehdi, MEHRZAD, Jamshid, GORINCIOI, Elena, SANTANIELLO, Enzo. Antiproliferative activity of N6-isopentenyladenosine on HCT-15 colon carcinoma cell line. In: Nucleic Acid Therapeutics, 2011, vol. 21, nr. 5, pp. 355-358. ISSN 2159-3337. DOI: https://doi.org/10.1089/nat.2011.0314 |
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  Nucleic Acid Therapeutics |
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| Volumul 21, Numărul 5 / 2011 / ISSN 2159-3337 /ISSNe 2159-3345 | ||||||
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| DOI:https://doi.org/10.1089/nat.2011.0314 | ||||||
| Pag. 355-358 | ||||||
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N6-Isopentenyladenosine (iPA), a member of the cytokinin family of plant hormones, exerts remarkable inhibition on tumor cell proliferation and apoptosis in several tumor cell lines. In this study, we report that iPA is able to inhibit the proliferation and promotes apoptosis in HCT-15 human colon cancer cells in a dose-dependent manner with a concentration of 2.5 μM, which causes 50% inhibition of cell viability. The cell cycle analysis by flow cytometry showed that iPA-induced growth arrest could be associated to apoptosis. Moreover, suppression of clonogenic activity occurs after exposure to iPA at a concentration of 2.5 μM for HCT-15. |
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| Cuvinte-cheie Antineoplastic Agents, apoptosis, carcinoma, Cell Cycle Checkpoints, Cell Line, tumor, cell proliferation, Cell Shape, Colonic Neoplasms, Dose-Response Relationship, drug, Humans, Isopentenyladenosine |
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