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Ultima descărcare din IBN: 2023-09-18 15:18 |
SM ISO690:2012 BARB, Alina Cristina, PASCA FENESAN, Mihaela, PIRTEA, Marilena, MARGAN, Madalin-Marius, TOMESCU, Larisa Cristina, MELNIC, Eugen, CIMPEAN, Anca-Maria. Tertiary Lymphoid Structures (TLSs) and Stromal Blood Vessels Have Significant and Heterogeneous Impact on Recurrence, Lymphovascular and Perineural Invasion amongst Breast Cancer Molecular Subtypes. In: Cells, 2023, vol. 12, pp. 1-16. ISSN 2073-4409. DOI: https://doi.org/10.3390/cells12081176 |
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Cells | |
Volumul 12 / 2023 / ISSN 2073-4409 | |
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DOI:https://doi.org/10.3390/cells12081176 | |
Pag. 1-16 | |
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Background: Tertiary lymphoid structures (TLSs) mediate local antitumor immunity, and interest in them significantly increased since cancer immunotherapy was implemented. We examined TLS− tumor stromal blood vessel interplay for each breast cancer (BC) molecular subtype related to recurrence, lymphovascular invasion (LVI), and perineural invasion (PnI). Methods: TLSs were quantified on hematoxylin and eosin stain specimens followed by CD34/smooth muscle actin (SMA) double immunostaining for stromal blood vessel maturation assessment. Statistical analysis linked microscopy to recurrence, LVI, and PnI. Results: TLS negative (TLS−) subgroups in each BC molecular subtype (except to Luminal A) have higher LVI, PnI, and recurrence. A significant rise in LVI and PnI were observed for the HER2+/TLS− subgroup (p < 0.001). The triple negative breast cancer (TNBC)/TLS− subgroup had the highest recurrence and invasion risk which was also significantly related to tumor grade. PnI but not LVI significantly influenced recurrence in the TNBC/TLS+ subgroup (p < 0.001). TLS−stromal blood vessel interrelation was different amongst BC molecular subtypes. Conclusion: BC invasion and recurrence are strongly influenced by TLS presence and stromal blood vessels, especially for HER2 and TNBC BC molecular subtypes. |
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Cuvinte-cheie breast cancer molecular subtypes, immature blood vessels, lymphovascular invasion, mature blood vessels, perineural invasion, recurrence, tertiary lymphoid structure, TLS |
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