The analysis of the main problems and dysfunctions of the tourist field in the development regions, as well as the effects they produce separately or aggregated, suggests the formulation of some challenges for the development of the tourism industry in the Republic of Moldova. The major problems of the Moldavian tourism industry, which are systematized and overlapped on the attributions of the deciding factors in tourism, allows through this research to present a systematized framework of problems to be solved for the country's development as an attractive tourist destination in all development regions. In this respect, the state policy and strategy regarding the tourism development of the Republic of Moldova must be elaborated and realized based on the concept of sustainable development.