During the last decade, a new class of porous hybrid materials (MOFs) was developed at the interface of materials science and coordina-tion chemistry, with various applications in adsorption, storage and gas se-paration, catalysis, magnetism, photoluminescence, linear optics, electron-ics, etc. MOFs are crystalline materials built up by organic ligands (func-tional molecules possessing donor atoms (N, O, S, etc.) in their structure) and metal centers (metal ions or clusters). The main advantage of MOFs arises from their variety of the structural and chemical composition, which facilitate the design by synthesis and allow the property optimization. MOFs research has shown that these materials are highly efficient in gas storage and separation, possessing high porosity and large specific area, being also excellent alternatives in adsorption and removal of harmful and toxic chemicals. Recently, MOFs proved a high performance in the retention of vola-tile acetic acids traces in moisture conditions found in archives or in mu-seum. To date, hydrophobic Fe3+, Al3+ and Zr4+-based MOFs have been proper functionalized for effective application in conservation of cultural heritage, the most promising one being Zr-MOF (UiO-66-2CF3). As alter-natives, stable and hydrophobic MOFs can be designed by introducing highly hydrophobic siloxane sequences in the ligand structure or by post-hydrophobization approaches with PDMS or organic polymers. *Aknowledgements: This work was supported by a grant of the Romanian Ministry of Research, Innovation and Digitalization, CNCS - UEFISCDI, project number PN-III-P4-IDPCE-2020-2000, within PNCDI III, Contract 207/2021 (2DPerMONSil).