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577.2+616-092.18 (1) |
Bazele materiale ale vieții. Biochimie. Biologie moleculară. Biofizică (664) |
Patologie. Medicină clinică (6964) |
SM ISO690:2012 SIDORENKO, Ludmila. Association between copy number variants at human salivary (AMY1) amylase gene and metabolic status. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 17. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 577.2+616-092.18 | ||||||
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Background. Gene encoding salivary amylase (AMY1) presents some of the greatest copy numbers of any human gene. There is evidence of a direct association between salivary alfa-amylase (SAA) and stress, as well as an inverse association between SAA and BMI. Objective of the study. To study the stress-related SAA levels in association with functional cardiovascular biomarkers for determining metabolic status changes. Material and Methods. 35 individuals, aged 35-45, with remarkable stress levels were included. The stress level was identified by Task-Force Monitor System. It was evaluated at baseline, so before the anti-stress treatment course, after it, and two months afterward. At the same time, SAA probes were taken. Those were further analyzed in the ILM laboratory in Leipzig, Germany. Results. In all 35 cases, SAA probes were taken at least one hour after meal intake, so it was not a post-prandial SAA. In 29 cases out of 35 was observed a direct correlation between SAA and stress levels (p<0.01). A reliable functional cardiovascular control parameter to check the dynamic of the stress-induced SAA changes was pNN50. It stood in inverse association with SAA level in all cases. SAA quantitatively varies in individuals of the same stress level group. In 6 individuals with a high-stress level, low quantities of SAA were detected. The determined SAA levels correlated inversely with the BMI in 34 out of 35 cases. Conclusion. Individuals with a low level of SAA had high BMI and were prone to develop diabetes mellitus and obesity. The higher AMY1 copy number favorable influences the metabolic status. The non-post-prandial level of SAA is applicable as a stress biomarker. |
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Cuvinte-cheie AMY1 gene, salivary amylase, BMI, stress biomarkers, gena AMY1, amilază salivară, IMC, biomarkeri de stres |
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