In the last fifty years, pesticides of chemical origin were very actively used, which undoubte-dly led to an increase in agricultural production, both quantitatively and qualitatively, and influen-ced the spread in certain areas and of different crops, which were more difficult before. But people started using these products without examining their impact on the environment and without taking into account that other generations will also need this habitat to develop. Use of pesticides contrary to recommendations led to air, water and soil pollution. Residues generated during the degradation of many active substances from pesticides are present in the environment for a long time, for exam-ple, even today large amounts of DDT are detected in the tissues of marine animals.  After society became aware that residues from the environment end up in human food, being the cause of various ailments, a campaign to tighten the standards began. In the last decades a very wide range of active substances have been excluded from the market or their use has been greatly limited. Along with the limitation of the use of some classes of substances and the tendency to develop organic and sustainable agriculture, there has been a shortage of preparations that could be used to solve the problems created by phytopathogenic and harmful agents [1, 2].  Biorational pesticides are products that have a maximum effect on the target and a minimum effect on the environment. Almost 90% of the microbial biopesticides currently available on the market are derived from a single entomopathogenic bacterium, i.e., Bacillus thuringiensis or Bt. Currently, biopesticides comprise a small portion of the total global crop protection market, va-lued at approximately $3 billion worldwide, accounting for only 5% of the total crop protection market. More than 200 products are available in the United States (US) market, compared to 60 similar products produced in the European Union (EU) market [3]. Although the use of biological pesticides on a global scale is increasing by 10% every year, it seems that the global market needs to grow further in the future if these pesticides are to play a visible role in replacing chemical pesticides and reducing the current over-reliance on them [3]. To solve some of the problems we propose to use the metabolite called spinosad, which is a complex of secondary metabolites syn-thesized by Saccharopolyspora spinosa [4]. Initially we propose to test this metabolite for aphids control under protected soil conditions, which will allow more detailed follow-up of the effects and in case they will have environmental effects they will be minimal [5].