This paper would like to review the literature concerning the coupling of High Performance Liquid Chromatography (HPLC) with the Electrochemical Detection (ED). HPLC is an analytical separation technique to which a detector is coupled at the outlet of the chromatographic column. There is currently no universal detector for HPLC. Electrochemical sensors are competitive with respect to the detectors currently used. In terms of sensitivity and selectivity no optical detector (e.g., UV-Vis, Fluorescence, Refractive Index RI) nor aerosol-based detector (i.e., Evaporative Light Scattering Detector ELSD, Nano Quantity Analyte Detector NQAD, Charged Aerosol Detector CAD) can compete with the electrochemical detector. Whenever an analyte is electroactive, i.e., can undergo oxidation or reduction, electrochemical detection (ED) can be applied. HPLC-ED approach is an extremely selective and sensitive detection technique that is applied in many analyses in agricultural, environmental and food field. It should be considered that ED has an enormous linear dynamic range of more than 6 orders of magnitude. This means that concentrations as low as 10 pmol L-1 and as high as 500 μmol L-1 or more can be detected. The papers present in literature on the HPLC-ED technique applied to resveratrol, rosmarinic acid, aromatic heterocyclic amines and glyphosate in matrices such as meat, aromatic plants, fruit and tomato juices, will be analyzed and discussed. The aforementioned papers have shown that electrochemical sensors used as detectors for HPLC can offer better sensitivity values than other detectors. Furthermore, the use of specific working potentials allows to avoid matrix interference by almost exclusively determining the analytes of interest. It follows that the HPLCED has a selectivity that allows to limit the sample preparation and clean-up procedures to a minimum, making it quick and easy to apply. In addition, this method offers advantages such as: the possibility of direct analysis, as derivatization is often not necessary, the cost-effectiveness of the instrumentation and the possibility of regenerating the electrodes which allows numerous analyzes in succession.