Introduction. Physical and mechanical parameters of biological materials has been studied more intensively since the 60-70 of the last century. At the moment, attempts are made to determine areas of weakness of the walls of hollow organs. Researches of this kind are required by rapidly increasing frequency of polytrauma, including the involvement of the organs of the abdominal cavity. Purpose. Determining the location of lesions in the duodenum wall after the experimentally induced baroresistance test. Material and methods. Study material was tested with a – system for establishing the baroresistance of hollow organs. An experimental study was conducted on 25 cases – people aged 21 to 87 years, 19 men and 6 women. Results. Thus, followed the establishment of duodenal wall areas with low baroresistance, where were taken into account portions of the duodenum, the number and length of breaks of the duodenal wall. So, macroscopic accessible tears of the duodenal wall were recorded mainly (32,0±8,52% - 8 observations) in the lower horizontal duodenum (DIII). Tears located within the DII – DIII were detected in 6 (24,0±7,79%) cases. Similar lesions located in the DIII and DIV occurred in 5 (20,0±7,30%) subjects. Isolated lesions of the walls of descending duodenum were found in 3 (12,0±5,93%) cases. Under the action of high pressure in the lumen DI solutions of continuity occurred in two (8,0±4,95%) cases. Isolated rupture at the level of the inferior duodenal flexure was observed in one case (4,0±3,58%). Conclusions. The resistance of human duodenum wall, to a certain extent, trends to reduce in distal direction from DI to DIV. It, also, is conditioned by the direction in which is applied the mechanical stress on the samples under examination – longitudinal or transverse. Evidence shows increased resistance limit to tensions in the longitudinal direction.