Introducere. Defectul septal ventricular (DSV) apare de obicei ca o patologie izolată sau ca unul din componentele unei asocieri de anomalii. Doar prin evidenţierea particularităţilor a DSV în aceste maladii, putem aprecia frecvenţa apariţiei şi gravitatea semnelor şi simptomelor ale acestui defect. Scopul lucrării. Determinarea factorilor ce influențează evoluția defectului septal ventricular izolat şi asociat cu alte maladii cardiace congenitale. Material şi metode. Studiu retrospectiv caz-martor a cuprins 88 pacienţi cu defect septal ventricular, care au fost divizaţi în două loturi: defect septal ventricular izolat şi asociat cu alte malformații congenitale de cord. Statistica: calcularea indicatorilor de frecvenţă, a valorilor medii, pragul de semnificaţie „p”, intervalul de confidenţă 95% (95CI). Rezultate. DSV izolat – 21,59% (95CI 14,28-31,28), p<0,01, DSV asociat – 78,40% (95CI 68,7285,72), p<0,01. DSV în cele mai dese ori se asociază cu defect septal atrial – 73,91% (95CI 62.4982.81), p=0,01. Dispneea este simptom principal în DSV izolat – 89,47% (95CI 68.61-97.06), p=0,01 şi simptomul principal în DSV asociat – 81,15% (95CI 70.39-88.64), p=0,01. Corecţie primară a DSV – 80,23% (95CI 70.60-87.28), p<0,01, chiar dacă defectul a fost asociat cu alte maladii cardiace congenitale. Concluzii. (1) Defect septal ventricular asociat cu malformaţii congenitale de cord se întîlneşte de 3,7 ori mai frecvent decât cel izolat. (2) Corecţie chirurgicală a maladiilor cardiace congenitale este orientată în primul rînd spre închiderea defectului septal ventricular – fie acest defect izolat sau asociat cu alte patologii.

Introduction. Septal ventricular defect (SVD) usually occurs like an isolate pathology and sometimes as a component of disease association. Due to the attention on particularities of SVD it is possible to appreciate the frequency of appearance and severity of signs and symptoms in this disease. Objective of the study. To evaluate the influential factors of evolution in septal ventricular defect like an isolate pathology or in association with congenital heart diseases. Material and methods. A retrospective study case-control in 88 patients within septal ventricular defect which were divised in two lots: septal ventricular defect like an isolate pathology and in association with congenital heart diseases. Statistics: calculation of incidence, the approximate value, the significance of the p value, the confidential interval (CI). Results. The isolated SVD – 21.59% (95CI 14.28-31.28), p<0.01,the associated SVD – 78.40% (95CI 68.72-85.72), p<0.01. In most cases SVD is associated with septal atrial defect – 73.91% (95CI 62.4982.81), p=0.01. The dispneya is the cardinal symptom of an isolated SVD – 89.47% (95CI 68.6197.06), p=0.01 and the cardinal symptom of an associated SVD – 81.15% (95CI 70.39-88.64), p=0,01. The primary correction of SVD – 80.23% (95CI 70.60-87.28), p<0.01, even the defect was associated with other congenital heart diseases. Conclusions. (1) The septal ventricular defect associated with congenital heart diseases is 3,7 times higher than isolated defect of the ventricle. (2) The surgical correction of congenital heart diseases is directed first of all on closure of that defect – whatever it is isolated or associated with other congenital heart diseases.