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Articolul urmator |
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Ultima descărcare din IBN: 2023-03-06 19:53 |
SM ISO690:2012 CERNEV, Daniela. Factorii de risc și prognosticul evoluției clinice în papilomatoza laringiană recidivantă. reviul literaturii. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 471. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Background. Recurrent laryngeal papillomatosis (RLP) is a rare, chronic pathology caused by HPV infection and is characterized by the development of exophyte proliferative lesions of the connective tissue covered by the epithelium, which affects the mucosa of the upper respiratory tract. Objective of the study. Evaluation of the etiological aspects, risk factors and prognosis of the clinical evolution of RLP according to the literature review. Material and Methods. We probed the database-based literature: Embase, MedLine, and Evidence-Based Medicine Reviews, using various keyword combinations related to the etiology of laryngeal papillomatosis, risk factors, and disease severity. Results. Seven long-term studies were analyzed, which showed that RLP occurs more frequently in patients with pathological laryngopharyngeal reflux that was diagnosed in 8/20 (40.0%) adults and 5/11 children (45.5%). Moreover, logistic regression revealed that only age at onset was associated with aggressive disease in young people, while HPV-11 and observation time> 10 years were risk factors in adults. Conclusion. RLP associated with HPV-11 behaves more aggressively: younger patients with HPV-11 and older with HPV-6 develop more severe clinical evolution. Laryngopharyngeal reflux may be a risk factor in the development of laryngeal papillomatosis, by activating or reactivating a latent HPV infection. |
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Cuvinte-cheie recurrent laryngeal papillomatosis, HPV, risk factors, papilomatoza laringiană recidivantă, HPV, factori de risc |
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