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Ultima descărcare din IBN: 2021-11-30 21:13 |
SM ISO690:2012 PĂDURE, Cătălina. Aspectele molecular-genetice ale senescenței. In: Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, 21-23 octombrie 2020, Chişinău. Chişinău: USMF, 2020, p. 30. |
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Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” 2020 | ||||||
Congresul "Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”" Chişinău, Moldova, 21-23 octombrie 2020 | ||||||
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Background. Senescence is the last stage of the physiological development of the human body, in which the cell division stops and the accumulation of damaged cells takes place. Trigger factors are DNA damage, telomere shortening, activation of oncogenic mutations / inactivation of tumor suppressor genes. Objective of the study. To study the correlation between the molecular-genetic aspects of senescence and the exponential increase in the risk of developing malignant tumors with age. Material and Methods. Analysis of 25 PubMed scientific articles based on studies describing the aspects of senescence with reference to its influence on the development of cancer, and studies that describe aging as a major risk factor for cardiovascular, neurodegenerative and devastating diseases such as cancer. Results. Senescence has an impact on aging through 2 mechanisms. First, with age senescent cells accumulate in tissues, maintaining their status like this for years, affecting the normal structure and function. The second, senescence can limit the regenerative potential of adult stem cells. One explanation is that aged organisms accumulate more genetic, epigenetic changes than young do. Having shorter telomeres, higher levels of damaged DNA, aged organisms are more resistant to oncogene proliferation than young are. Studies have shown that a higher incidence of malignancies in old age reflects the time required for the accumulation of oncogenic mutations. Conclusion. For most adults, cancer should not be an inevitable outcome of aging. On the contrary, preventing or at least delaying the onset of cancer can be seen as an effective strategy for achieving a healthy and a long life. |
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Cuvinte-cheie Senescence, oncogenic mutations, DNA, aging, cancer, senescență, mutații oncogene, ADN, îmbătrânire, cancer |
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