Introduction. Hypertension (HBP) is defined as a blood pressure of over 140/90 mmHg in people aged 18 years or older. The global prevalence of HBP is about 15-37%, rising up to 50% in people older than 60 years old(y/o). According to CINDI study, in RM 30% of the population in between 25 and 64 y/o manifest this disease. Aim of the study. To present the essential differences of clinical features, diagnosis, treatment and evolution of HBP in women. Materials and methods. The study involved 214 hypertensive patients – 118 women and 96 men with the average age of 66 ± 4 y/o. Results. Our study showed that the HBP incidence is in accordance to gender and age; as such, before the age of 65 HBP is more common in men 1:2.29; in the interval of 55 and 65 y/o the ratio was 1:1, but after 65 y/o it is more frequent in women 1.46:1. Cardiovascular (CV) risk factors were predominant in women comparing to men and are represented by: dyslipidemia 72.9% vs 50%; obesity 54.3% vs 35.5%; sedentarism 84.7% vs 52.1% and hyperuricemia 22.1% vs 16.7 %. According to the severity of the disease, most of the women had HBP of 3rd grade 67.8% vs 60.4% associated with very high CV risk – 79.6% vs 70.8%. Complications of HBP were more common in men then women and were expressed by: hypertrophic cardiopathy 31.3% vs 28.8%; acute myocardial infarction (AMI) 10.3% vs 8.4%; stroke 10.3% vs 7.4%; while heart failure (96,6% vs 91,7%) and ischemic heart disease (86,5% vs 79.2%) were more frequent in women. Biochemical findings showed that hyperglycemia was prevalent in men 37.5% vs 28.8%, but changes in the lipid profile were more common in women: high levels of serum LDL (> 3 mmol/l) 47.5% vs 35.4%; TG (> 1,7 mmol/l) 38.9% vs 22.9%; cholesterol 56.3% vs 55.9% and low levels of serum HDL seric (<1,0 mmol/l) 47.5% vs 35.4%. ECG revealed that hypertrophy of left ventricle was more manifest in women 45.8% vs 31.9%. Echo-CG results showed no significant differences associated with gender. In treatment of HBP both women and men used a combined therapy of ≥ 2 drugs 86.5% (women) vs 85.4% (men). While the most popular combination of drugs in women were a beta-blocker(BB) + ACE inhibitor(ACEI) + diuretics (DT) 43.1%, in men it was represented by ACEI + DT 21,9%. Conclusions. HBP is a major risk factor of cardiovascular disease in women. Age has a decisive role in the debut and progression of the disease, thus, it usually appears in women older than 65 y/o, in post-menopause caused by hypoestrogenemia and hyperproduction of pituitary hormones, risk factors being obesity and sedentarism. The incidence of complications such as AMI and stroke in this interval of age is equal for both men and women, while pre-menopause women are less affected due to the protective role of estrogen.